Decreased expression of HBV surface antigen (HBsAg) with sK122R and sV96A co-mutation is associated with an ineffective antibody response in a chronic hepatitis B patientArticle Published on 2023-07-012023-06-11 Journal: Infection, genetics and evolution : journal of mol [Category] B형 간염, [키워드] amino acid substitution Antibody Response antigenicity HBsAg sK122R sV96A. [DOI] 10.1016/j.meegid.2023.105431 PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
A comprehensive update on CIDO: the community-based coronavirus infectious disease ontologyArticle Published on 2022-10-212022-11-16 Journal: Journal of Biomedical Semantics [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] aligned Amino acid amino acid substitution Analysis applied basic Clinical data clinical trial coronavirus coronavirus coronavirus disease COVID-19 COVID-19 pandemic Delta Diagnosis diagnostic disease domain drug Drug repurposing drug-target effective Epidemiology evaluated example Formal global public health heterogeneous Human Infectious disease initiated knowledge Metadata omicron ontologies Ontology outbreak phenotype PPI protein-protein interaction Safe SARS-CoV-2 SARS-CoV-2 protein Standardization Support supported target protein Treatment Vaccine vaccine. variant variants variants of SARS-CoV-2 virus [DOI] 10.1186/s13326-022-00279-z PMC 바로가기
Genetic diversity and evolutionary convergence of cryptic SARS- CoV-2 lineages detected via wastewater sequencingArticle Published on 2022-10-142022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Alpha VOC amino acid substitution amplify approach Course effective Epidemiology genetic diversity greater increasingly Infection Lineage lineages majority mutated New York City occurred omicron over Patient RBD Receptor binding domain reservoirs residue resolved SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 surveillance sequence Sequencing Spread substitutions the RBD USA variant viral lineage VoC wastewater while [DOI] 10.1371/journal.ppat.1010636 PMC 바로가기
Detection of SARS-CoV-2 in a dog with hemorrhagic diarrheaArticle Published on 2022-10-122022-11-15 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Affect African amino acid substitution analyzed Asymptomatic B.1.177 Bacterial Cell Ceuta characteristic circulation coronavirus COVID-19 detection diarrhea disease dog Dog COVID-19 excluded fecal gastrointestinal tract Genome Hemorrhagic Highland human SARS-CoV-2 human-to-animal transmission Ile402Val S protein substitution Infection Interaction intrinsic knowledge mapped microbial Microbiome MOST negative test Next-generation sequencing NGS North one health pandemic Pathogens pathology positive presenting RBD Receptor binding domain reported RT-PCR test S protein SARS-CoV-2 SARS-CoV-2 genome sequence Sequencing Spain Spanish suffered Terrier the S protein the spike protein USA variant viral loads viral variant virus West zoonosis. [DOI] 10.1186/s12917-022-03453-8 PMC 바로가기
Dynamic SARS-CoV-2 emergence algorithm for rationally-designed logical next-generation vaccinesArticle Published on 2022-10-102022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Algorithm amino acid substitution change Clinical efficacy clinical sample correlation D614G decrease determine dynamic Efficacy Endemic epitope Epitopes Evolution Evolution of SARS-CoV-2 immune immunogenic indicated lineages mAb monitoring monoclonal antibodies Mutation mutations Pearson positive positive correlation predicted Predictive Prevalence prevalent resulting SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome spike mutation Spike protein Spread Substitution Vaccine Vaccine design variant virus [DOI] 10.1038/s42003-022-04030-3 PMC 바로가기
Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2Article Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome amino acid substitution amubarvimab (BRII-196) antibody antibody cocktail Clinical efficacy Combination controls coronavirus coronavirus disease COVID-19 demonstrated Emergency use authorization epitope EUA Evolution half-maximal inhibitory concentration half-maximal inhibitory concentration (IC50) in vitro introduced less Lung pathology Lungs M252Y/S254T/T256E (YTE) mAb mAbs Modification monoclonal antibody monoclonal antibody (mAb) Mutation neutralize neutralized Neutralizing Post-infection Preclinical RBD receiving Receptor binding domain receptor binding domain (RBD) reduce reduced regions regulatory authority resulting retained romlusevimab (BRII-198) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly Spike protein Support susceptibility therapeutic option variant Variant of concern (VOC). variants variants of concern Viral load virus virus VoC weight loss [DOI] 10.3389/fimmu.2022.980435 PMC 바로가기
Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike proteinArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 receptor acute respiratory syndrome amino acid substitution Cell cell display coronavirus COVID-19 Effect Epitopes expression flow cytometry glycoprotein high throughput Host immune evasion implicated INDEL mechanism molecular Mutation mutations N-terminal neutralizing antibody nonsynonymous omicron Receptor binding domain repeated S2 domain SARS-CoV-2 spike mutation Spike protein Spread the SARS-CoV-2 the spike protein Transmissibility variant variants of concern variety viral glycoprotein. VOCs [DOI] 10.1016/j.chom.2022.07.016 PMC 바로가기
Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases serine proteases. Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기
Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineagesArticle Published on 2022-09-012022-11-16 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated African amino acid substitution analysis AY.1 B.1.617.2 B.1.621 binding binding interaction China Combination Complexes COVID-19 Delta docking domain Effect exhibited Factors Genetic hACE2 hACE2. Host human Angiotensin-converting enzyme Interaction investigated Latin Lineage missense variant Missense variants MM/GBSA molecular docking molecular docking analysis molecular dynamics Molecular dynamics simulation MOST Mutation mutations non-Finnish European omicron Population populations predict prevalent protein stability rate of infection RBD Receptor binding risk SARS-CoV-2 SARS-CoV-2 RBD South Asian spike glycoprotein suffered the SARS-CoV-2 Transmissibility variant variants variants of concern viral variant virus was performed Wuhan [DOI] 10.1016/j.compbiomed.2022.105903 PMC 바로가기